Nov 9 - Dec 31, 2017

Key for a Cure Foundation

Mission

The mission of the foundation is to raise funds to directly support innovative pediatric cancer research that will lead to more effective treatments for children with cancer.

Key for a Cure Foundation is committed to fighting pediatric cancer. The foundation is currently working to raise funds for T cell based Immunotherapy research being conducted at St. Jude Children’s Research Hospital. The foundation raised $250,000.00 in the first year after the non-profit was established and donated the funds to this innovative research protocol.

The Big Idea

Programmed T cells that searching for cellular abnormalities such as cancerous cells and infections is the future of cancer treatment.

T cells are a type of white blood cell that circulates throughout the body, searching for cellular abnormalities such as cancerous cells and infections. T cells have two unique features that fight tumors. First, each T cell possesses a unique receptor that allows it to identify potential threats. One of the potential threats that T cells can target are tumor cells. Second, once a tumor cell is identified as a threat, the T cell can directly kill it.
While therapies utilizing this natural immune response are highly effective in treating some cancer patients, they are unsuccessful in others. That failure is sometimes the result of the tumor cell evading recognition by the T cell’s receptor and sometimes because the cancerous cell is able to repress the T cell’s killing function, leaving them in an “exhausted” state. Funding provided by the Key for a Cure Foundation will be used to build upon the progress made and to support:
1. Use the epigenetic studies to develop more
durable T cells; 2. Further test candidate antigens for effectiveness at targeting tumors; and 3. Look more closely at the way T cell receptors recognize tumors with the goal to develop new targeted therapeutics.

My grandson will not benefit from the work being conducted at Key for a Cure Foundation but the next child like Matthew will and that is why it’s so important to fund research that will find effective cancer treatment for children. Matthew did not pass away from his terminal disease but from the toxic effects of his cancer treatment.

— Rachel Grijalva, Age 65, Salinas